The AGA’s clinical guidelines are evidence-based recommendations to help guide your clinical practice decisions based on rigorous systematic reviews of the medical literature.

AGA utilizes the GRADE system (Grades of Recommendation Assessment, Development and Evaluation). Learn about GRADE. Our guidelines are regularly reviewed for accuracy. Learn about the update process. AGA endorses guidelines that meet the IOM's rigorous criteria for evidence-based clinical recommendations. Endorsement criteria and methods.

AGA Clinical Guidelines App

AGA Clinical Guidelines App

Access AGA's clinical guidelines at the point of care.

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AGA Pocket Guides

AGA Devices

Official AGA Institute quick-reference tools provide healthcare providers and students with instant access to current guidelines and clinical care pathways in a clear, concise format. AGA Institute pocket guides are available in print and digital form.

AGA members: Purchase print copies or download digital versions for free.

Non-members: Access print and digital copies available for purchase.

Click the arrow on the right of each category to view related guidelines, clinical support tools, and other evidence-based practice resources.

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Colorectal Cancer

In the U.S., colorectal cancer (CRC) is the third most common cancer diagnosed among men and women and the second leading cause of death from cancer. CRC largely can be prevented by the detection and removal of adenomatous polyps. AGA offers a broad portfolio of guidelines, decision support tools and standards to support high-quality patient care.

Screening for Early Detection

Colorectal Cancer Screening and Surveillance for Early Detection

Guideline | PDF | Algorithm

Colonoscopy After Cancer Resection

Colonoscopy Surveillance After Cancer Resection

Guideline | PDF | Algorithm


Colonoscopy After Polypectomy

Colonoscopy Surveillance After Screening and Polypectomy

Guideline | PDF | Algorithm | Interactive Algorithm | Recommendations


Lynch Syndrome

Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Guideline | PDF

Bowel Cleansing

Optimizing Adequacy of Bowel Cleansing for Colonoscopy: Recommendations From the US Multi-Society Task Force on Colorectal Cancer

Guideline | PDF

AGA Guideline on the Diagnosis and Management of Lynch Syndrome

Guideline | PDF | Patient Guide | Algorithm | Interactive Algorithm | Recommendations | Technical Review



The two inflammatory bowel diseases (IBD) are Crohn’s disease and ulcerative colitis (UC). Most care for these chronic diseases occurs in the outpatient setting, with hospitalizations reserved for complications that might require surgery. AGA offers a guideline on drug therapy and decision support tools for patient management.

Crohn’s Disease

Guidelines for the Identification, Assessment and Initial Medical Treatment in Crohn’s Disease

Interactive Clinical Care Pathway | Clinical Care Pathway

Drug Therapy for Crohn’s

Inflammatory Crohn’s Disease: Thiopurines, Methotrexate and Anti-TNF-α Biologic Drugs for Induction and Maintenance of Remission

Guideline | Algorithm | Interactive Algorithm | Patient Guide | Recommendations | Technical Review

Ulcerative Colitis

Identification, Assessment and Initial Medical Treatment of Ulcerative Colitis

Clinical Care Pathway | Algorithm




Medical Management of Microscopic Colitis

Guideline | PDF | Technical Review | Algorithm | Interactive Algorithm | Patient Guide | Recommendations

Management of Crohn's Disease After Surgery

Guideline | PDF | Algorithm | Technical Review | Patient Guide



Therapeutic Drug Monitoring in IBD

Guideline | PDF | Technical Review | Algorithm | Patient Guide




Please note that the above guidelines do not include recommendations for the use of newer drugs approved for the treatment of IBD (i.e., vedolizumab, ustekinumab) due to a lack of currently availability evidence from which to draw recommendations. All guidelines are regularly assessed for update as new data are published.


Esophageal Diseases

Two of the most common esophageal diseases seen by gastroenterologists are Barrett’s esophagus and GERD. AGA resources focus on major clinical issues encountered by physicians who treat patients with Barrett's esophagus and the general issues related to managing GERD.

Barrett's Esophagus

Barrett's Esophagus

Guideline | PDF | Technical Review

Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease (GERD)

Guideline | PDF | Technical Review

Upper-GI Biopsy to Evaluate Dyspepsia

Guideline | PDF | Algorithm | Interactive Algorithm | Technical Review | Recommendations


Liver Diseases

AGA’s liver disease resources include guidelines and decision tools for hepatitis C screening and evaluation, how to handle hepatitis B reactivation during immunosuppressive therapy and managing NAFLD patients.

Hepatitis C

Hepatitis C Screening and Evaluation

Clinical Care Pathway | Full article

Hepatitis B Reactivation

Hepatitis B Reactivation During Immunosuppressive Drug Therapy

Guideline | Algorithm | Interactive Algorithm | Patient Guide | Recommendations | Technical Review

Nonalcoholic Fatty Liver Disease

Nonalcoholic Fatty Liver Disease

Guideline | PDF




Role of Elastography in the Evaluation of Liver Fibrosis

Guideline | Technical Review

Acute Liver Failure

Guideline | Technical Review


Pancreatic Disorders

Acute pancreatitis is a disease of increasing annual incidence and one that produces significant morbidity and mortality and consumes enormous health care resources. AGA provides guidelines to guide clinicians in the management of patients with both mild and severe acute pancreatitis.

Acute Pancreatitis

Acute Pancreatitis

Guideline | Technical Review

Irritable Bowel Syndrome

IBS is the most common diagnosis in clinical gastroenterology. It is estimated that approximately 10 to 15 percent of the general adult population is affected. AGA offers recommendations about pharmacological therapy for IBS-C (constipation) and IBS-D (diarrhea).

Drug Management

Irritable Bowel Syndrome: Guideline on Pharmacological Management

Guideline | PDF | Recommendations | Technical Review | Patient Guide

Functional GI Disorders

Functional GI disorders affect patient quality of life. AGA offers a growing portfolio of resources to help care for patients with these disorders.


Upcoming Guidelines

Clinical practice guidelines are developed under the aegis of the AGA Institute Clinical Guideline Committee and provide preferred approaches to specific medical problems or issues.

Guideline Topic Expected Publication Date
Initial Management of Acute Pancreatitis March 2018
Management of Opioid-Induced Constipation Summer 2018
Update on the 2014 Guideline on the Pharmacological Management of Irritable Bowel Syndrome Summer 2018
Evaluation of Functional Diarrhea Summer 2018
GI Cancer Survillance in Gastric Intestinal Metaplasia Fall 2018
Management of Mild to Moderate Ulcerative Colitis Fall 2018
Management of Eosinophilic Esophagitis Fall 2018
Role of Probiotics in the Management of GI Disease Spring 2019
Management of Moderate to Severe Ulcerative Colitis Spring 2019
GI Evaluation of Iron Deficiency Anemia Spring 2019