2015-02-17 18:52:16 UTC

Antidepressants May Benefit a Subgroup of Patients with GERD

Feb. 19, 2015

Reporting in Clinical Gastroenterology and Hepatology, Pim W. Weijenborg and colleagues find that antidepressants modulate esophageal sensation and reduce functional chest pain.

Patients with functional esophageal disorders present with symptoms of chest pain, heartburn, dysphagia or globus in the absence of any structural abnormality. Visceral hypersensitivity is a feature of these functional disorders, and might be modulated by antidepressant therapy. Pim W. Weijenborg and colleagues evaluated evidence for the efficacy of antidepressant therapy for symptoms associated with esophageal visceral hypersensitivity in patients with functional esophageal disorders or GERD. Reporting in Clinical Gastroenterology and Hepatology, they find that, based on a systematic review, antidepressants modulate esophageal sensation and reduce functional chest pain. There is limited evidence that antidepressants benefit a subgroup of patients with GERD. More controlled trials are needed to investigate the effects of antidepressants on functional esophageal disorders. 

Clinical Gastroenterology and Hepatology 2015: 13(2): 251-259.e1

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