2014-02-11 13:36:13 UTC

Association Between H. pylori and Barrett's Esophagus

Feb. 20, 2014

Joel H. Rubenstein and colleagues report in Clinical Gastroenterology and Hepatology that, based on a case-control study, infection with Helicobacter pylori (H. pylori), particularly the cagA+ strain, is associated inversely with Barrett's esophagus.

Infection with Helicobacter pylori (H. pylori), particularly the cytotoxin-associated gene A (cagA)+ strain, is believed to protect against Barrett's esophagus, but it is not clear if it protects against gastroesophageal reflux disease (GERD). Joel H. Rubenstein and colleagues aimed to determine whether H. pylori infection is associated with GERD symptoms, erosive esophagitis and Barrett's esophagus within the same cohort. They report in Clinical Gastroenterology and Hepatology that, based on a case–control study, infection with H. pylori, particularly the cagA+ strain, is associated inversely with Barrett's esophagus. The investigators observed a trend toward an inverse association with esophagitis, but not with GERD symptoms.

Clinical Gastroenterology and Hepatology 2014: 12(2): 239-245

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