2012-07-24 13:08:29 UTC

Esophageal Acid Exposure Greatest Among the Overweight

July 24, 2012

Results published in Clinical Gastroenterology and Hepatology showing a significant association between BMI and esophageal acid exposure have implications for benefit of weight loss in patients with suspected extraesophageal manifestations of GERD

Obesity is believed to be an important etiologic factor in gastroesophageal reflux disease (GERD). However, it is not clear how obesity might affect esophageal acid exposure in patients with extraesophageal manifestations of reflux.

In a cross-sectional study of 223 patients with extraesophageal symptoms suspected of being related to reflux, esophageal acid exposure was associated significantly (P < .001) with BMI. The percentage of time at a pH less than 4 and total symptomatic reflux events increased significantly (P = .005) with increasing BMI.

Increases in esophageal acid exposure are greatest among overweight patients and plateau in obese patients. The findings have implications for benefit of weight loss in patients with suspected extraesophageal manifestations of GERD.

Clinical Gastroenterology and Hepatology 2012: 10(8): 874-878

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