2013-10-08 13:21:00 UTC

Gliadin Does Not Induce Mucosal Inflammation or Basophil Activation in Patients with NCGS

Oct. 10, 2013

Cristina Bucci and colleagues report in Clinical Gastroenterology and Hepatology that, unlike the duodenal mucosa from patients with celiac disease, upon incubation with gliadin, mucosa from patients with nonceliac gluten-sensitive (NCGS) does not express markers of inflammation, and their basophils are not activated by gliadin.

Nonceliac gluten-sensitive (NCGS) patients report intestinal and extra-intestinal symptoms shortly after ingesting gluten; these symptoms disappear on gluten-free diets, although these patients have no serologic markers of celiac disease or intestinal damage. In fact, there is no evidence for mucosal or serologic modifications in those individuals. Cristina Bucci and colleagues investigated immunologic responses of duodenal mucosa samples and peripheral blood basophils, isolated from NCGS patients, after exposure to gliadin. They report in Clinical Gastroenterology and Hepatology that, unlike the duodenal mucosa from patients with celiac disease, upon incubation with gliadin, mucosa from patients with NCGS does not express markers of inflammation, and their basophils are not activated by gliadin. The in vitro gliadin challenge therefore should not be used to diagnose NCGS.

Clinical Gastroenterology and Hepatology 2013: 11(10): 1294-1299.e1

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