2015-02-09 20:52:37 UTC

Mucosal Impedance Discriminates GERD From Non-GERD Conditions

Feb. 5, 2015

Fehmi Ates and colleagues report in Gastroenterology that measurements of mucosal impedance detect GERD with higher levels of specificity and positive predictive values than wireless pH monitoring.

Current diagnostic tests for GERD are suboptimal and do not accurately and reliably measure chronicity of reflux. A minimally invasive device has been developed to assess esophageal mucosal impedance (MI) as a marker of chronic reflux. Fehmi Ates and colleagues performed a prospective longitudinal study to investigate MI patterns in patients with GERD and common nonreflux conditions to assess MI patterns before and after treatment with proton pump inhibitors, and to compare the performance of MI and wireless pH tests. They report in Gastroenterology that, based on a prospective study using a prototype device, measurements of MI detect GERD with higher levels of specificity and positive predictive values than wireless pH monitoring.

Gastroenterology 2015: 148(2): 334-343

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