2011-10-11 14:56:00 UTC

PPI Therapy Improves Unexplained Chest Pain in GERD

Oct. 15, 2011

Unexplained chest pain in patients with endoscopic or pH monitoring evidence of GERD tends to improve, but not resolve, with PPI therapy, whereas GERD-negative patients have little or no response.

Unexplained chest pain is potentially attributable to GERD or esophageal motility disorders. Reflux chest pain may occur without heartburn. According to study results published in Gut, unexplained chest pain in patients with endoscopic or pH monitoring evidence of GERD tends to improve, but not resolve, with PPI therapy, whereas GERD-negative patients have little or no response. Heartburn was a poor predictor of whether patients with chest pain were GERD-positive or GERD-negative by objective testing.

Gut 2011; 60: 1473-1478

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