2012-03-20 13:38:25 UTC

Predictors of Response to PPIs in GERD

March 22, 2012

Approximately 30 percent of patients with GERD do not achieve adequate symptom control with proton pump inhibitors (PPIs). Doctors found that clinical, but not esophageal pH-impedance, profiles can predict response to PPIs in GERD.

Approximately 30 percent of patients with GERD do not achieve adequate symptom control with proton pump inhibitors (PPIs). In a study published in Gut, a team of doctors from France determined whether any symptom profile or reflux pattern was associated with refractoriness to PPI therapy; both clinical and reflux parameters were taken into account for multivariate analysis. Results showed that clinical, but not esophageal pH-impedance, profiles predict response to PPIs in GERD.

Gut 2012: 61: 501-506

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