2017-07-19 19:43:30 UTC

Research Update: PPIs Do Not Cause Dementia

July 20, 2017

New Gastroenterology research from Andrew T. Chan and colleagues helps clarify the connection between PPIs and cognitive function.

The latest update on proton-pump inhibitors (PPIs) and adverse risks comes to us from AGA's journal, Gastroenterology. In a new article in press, Andrew T. Chan, MD, MPH, and colleagues from Massachusetts General Hospital and Harvard Medical School, Boston, report that there is no convincing evidence to support the suggestion that PPI use increases dementia risk. These findings are based on an analysis of 13,864 participants from the Nurses’ Health Study II who completed testing on cognitive function, which is a key predictor of the risk of dementia later in life. 

This research directly responds to a 2016 pharmacoepidemiologic analysis conducted using a large German health insurance database, which identified an association between dementia and long-term PPI use. The findings, published in JAMA Neurology, could not illustrate that PPIs caused dementia; nonetheless, the article received significant media attention and caused alarm among patients.

To help you speak to your patients about risks associated with PPIs, AGA has updated its talking points on PPIs and dementia.

Have questions on this new research or PPIs in general? Head to the AGA Community and join the online discussion.

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